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KMID : 0939920150470020322
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대한암학회지
2015 Volume.47 No. 2 p.322 ~ p.328
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Primary Histiocytic Sarcoma of the Central Nervous System
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:So Hoon-Sub
:Kim Sun-A/:Yoon Dok-Hyun/:Khang Shin-Kwang/:Hwang Ji-Hye/:Suh Chong-Hyun/:Suh Cheol-Won
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Abstract
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Histiocytic sarcoma is a type of lymphoma that rarely involves the central nervous system (CNS). Its rarity can easily lead to a misdiagnosis. We describe a patient with primary CNS histocytic sarcoma involving the cerebral hemisphere and spinal cord, who had been initially misdiagnosed as demyelinating disease. Two biopsies were necessary before a correct diagnosis was made. A histologic examination showed bizarre shaped histiocytes with larger nuclei and nuclear atypia. The cells were positive for CD68, CD163, and S-100 protein. As a resection was not feasible due to multifocality, he was treated with highdose methotrexate, but showed no response. As a result, he was switched to high dose cytarabine; but again, showed no response. The patient died 2 months from the start of chemotherapy and 8 months from the onset of symptoms. Since few patients with this condition have been described and histopathology is difficult to diagnose, suspicion of the disease is essential.
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KEYWORD
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Histiocytic sarcoma, Central nervous system, Methotrexate, Cytarabine
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